01 Developmental Foundations

  N30(["INTERFEAR model"])
  N27(["Callous-unemotional traits"])
  N26(["Heterogeneity / equifinality"])
  N29(["Parenting / distress"])
  N46[/"Conduct-problem change"/]
  N18["2023 Fearlessness pathway"]
  N5["2016 Neurocognitive subtype constraint"]
  N4["2016 Fear / fearlessness"]
  N17["2023 Fear reactivity × parenting"]
  N3["2014 Parenting × CU"]
  N59{{"OPEN: biomarker-guided treatment matching"}}
  N19["2024 INTERFEAR five-wave test"]
  N2["2013 CU / conduct variants"]
  N1["2010 Developmental trajectories"]
  N28(["Fearlessness"])
  N1 -- "supports" --> N26
  N2 -- "supports" --> N26
  N26 -- "motivates" --> N4
  N4 -- "supports" --> N28
  N4 -- "supports" --> N26
  N5 -- "constrains" --> N26
  N3 -- "supports" --> N29
  N17 -- "supports" --> N29
  N18 -- "supports" --> N28
  N18 -- "supports" --> N29
  N19 -- "formalizes" --> N30
  N28 -- "integrates with" --> N29
  N27 -- "integrates with" --> N30
  N30 -- "predicts" --> N46
  N26 -. "motivates" .-> N59
  classDef gap stroke-width:3px,stroke-dasharray: 6 4;
  classDef constraint stroke-width:3px;
  classDef intervention stroke-width:2px;
  classDef mechanism stroke-width:2px;
  class N59 gap
  linkStyle 5 stroke-width:2px
  linkStyle 14 stroke-dasharray: 5 5