Bridge Relationship Register

Legend: documented = author/source explicit; strongly-inferred = high-confidence reconstruction; tentative = plausible but not yet provenance-complete.

Source	Relationship	Target	Confidence	Basis
2016 fear/fearlessness subgroup study	supports	heterogeneous fear pathways	documented	Study directly contrasts fear/fearlessness profiles.
2016 affective-response work	extends	psychophysiological differentiation	strongly-inferred	Adds facial/neural responding to subtype literature.
2017 primary/secondary startle work	supports	primary-secondary physiological differentiation	documented	Direct subgroup comparison.
2017 multidimensional psychophysiology	constrains	unitary psychopathy physiology	documented	Different dimensions show different physiological correlates.
2018 heterogeneity review	synthesizes	heterogeneous psychophysiology model	documented	Review is explicitly organized around heterogeneity.
2018 cross-age neurophysiology	extends	subtype-specific multi-system measurement	documented	Directly compares CU/anxiety/CP groups across child and young-adult samples.
2018 review / cross-age work	motivates	2019 meta-analytic constraint	strongly-inferred	Same broad psychophysiology problem; explicit citation link still to verify.
2019 meta-analysis	constrains	single-biomarker low-arousal theory	documented	Pooled findings differ by measure and design.
2019 VR fear study	introduces-method	VR emotion elicitation	documented	VR used to evoke fear while measuring physiology.
2018–2019 heterogeneity work	extends	2020 amygdala subtype study	strongly-inferred	Shared primary/secondary logic and threat-processing question.
2018–2019 emotion/heterogeneity work	extends	2020 eye-gaze variant study	strongly-inferred	Tests a more specific attentional explanation.
2018–2019 mechanism work	motivates	2020 cTBS DLPFC experiment	tentative	Intellectual continuity plausible; explicit lineage source still needed.
2020 eye-gaze variant study	extends	2022 child eye-gaze study	strongly-inferred	Same attentional mechanism tested in younger population.
2022 child eye-gaze work	tests-mechanism-of	2024 multi-method attention study	documented	Later paper explicitly tests CU assessment methods and emotion/gaze processing.
2024 multi-method attention study	constrains	simple eye-neglect / recognition-deficit account	documented	Recognition accuracy null; gaze pattern depends on CU measure.
2020 cTBS experiment	converges-with	facial-mimicry manipulation	tentative	Both manipulate proximal emotion-processing mechanisms by different routes.
2016 fear/fearlessness work	extends	2023 fear-reactivity × parental-distress study	strongly-inferred	Reuses physiological sensitivity while reintegrating environment.
2023 physiology × parenting	contextualizes	biological vulnerability claims	documented	Shows physiological reactivity moderating environmental associations.
2023 preschool facial-reactivity work	constrains	CU-specific affective-deficit account	documented	CP+CU and CP-only groups not consistently differentiated.
2023–2024 emotion-processing studies	converges-with	2024 parent-child sadness intervention	strongly-inferred	Moves from measuring emotion processing to deliberately modifying it.
2024 parent-child sadness intervention	intervenes-on	sadness recognition / autonomic response	documented	Proximal emotional/physiological endpoints deliberately targeted.
2020 cTBS emotion-recognition study	experimentally-supports	DLPFC contribution to selected emotion-recognition performance	documented	Real/sham manipulation; effects concentrated in elevated baseline APD symptom group.
baseline APD symptoms (2020)	moderates	cTBS emotion-recognition effect	documented	APD symptoms were measured pre-stimulation and used for median-split subgrouping.
2020 cTBS study	does-not-establish	APD/ASPD symptom reduction	documented-constraint	APD symptoms were not a post-treatment endpoint; sample had no APD diagnosis.
2020 cTBS study	motivates	repeated cTBS + AMT intervention	documented	2020 paper explicitly proposes combining TMS with attention modification in future work.
2025 cTBS + AMT study	supports	positive-attention / gaze mechanism change	documented	Active combined condition altered proximal attention/gaze outcomes.
2025 cTBS + AMT study	constrains	additive symptom efficacy of active cTBS	documented	Active cTBS + AMT was not superior to sham cTBS + AMT for anxiety reduction.
2025 emotional-attention cTBS study	experimentally-supports	DLPFC contribution to emotional attention	documented	Real cTBS altered dot-probe performance in healthy young adults.
Fanti 2026 brain-stimulation keynote claim	extends-beyond-located-evidence	APD/ASPD symptom reduction	documented-tension	Located Fanti-led studies support proximal emotional-processing changes but not direct APD/ASPD symptom reduction.

v0.3.9 source-hardened intervention-foundation relationships

2018-school-prevention -> distal-CU-CD-outcomes
- relation: supports
- historical_confidence: high
- evidentiary_confidence: moderate
- source_grade: A*
- qualification: only three school clusters; one treated school; treatment and school identity are not separable
broad-emotion-social-skill-training -> CU-CD-change
- relation: possible-mechanism
- historical_confidence: high
- evidentiary_confidence: low
- qualification: intended mechanisms were not directly measured in the 2018 trial
2024-parent-child-interventions -> sadness-recognition-change
- relation: supports
- historical_confidence: high
- evidentiary_confidence: moderate
- source_grade: B
- qualification: publisher abstract supports pre/post change but not programme-specific comparative superiority
2024-parent-child-interventions -> skin-conductance-response-to-sadness
- relation: supports
- historical_confidence: high
- evidentiary_confidence: moderate
- source_grade: B
- qualification: proximal physiological endpoint; programme-specific details not primary-full-text hardened
PCIT-CDI-CU -> uniquely-superior-sadness-processing
- relation: provisional
- historical_confidence: unresolved
- evidentiary_confidence: unresolved
- source_grade: E-secondary-detail
- genealogy_eligible: false
parent-child-sadness-processing -> reduced-CU-or-conduct-problems
- relation: open-inference-gate
- historical_confidence: moderate
- evidentiary_confidence: low
- qualification: distal trait/behavioral reduction was not established in the primary abstract