Evidence-Gated Edge Register — Genealogy v1
Evidence-Gated Edge Register — Genealogy v1
Historical confidence and evidentiary confidence are independent. An edge can be historically secure while the scientific inference it represents remains weak.
| Edge | Source | Relationship | Target | Hist. | Evid. | Grade | Population | Endpoint | Follow-up | Replication | Attribution | Inference boundary |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| E001 | STUDY-2010-TRAJ | supports | CONSTRUCT-HETEROGENEITY | high | moderate | B | exact | theoretical | longitudinal ages 2-12 | single-cohort | direct-fanti | Trajectory heterogeneity is descriptive/developmental, not causal mechanism proof |
| E002 | STUDY-2013-CUVAR | supports | CONSTRUCT-HETEROGENEITY | high | moderate | B | exact | theoretical | cross-sectional/variant | single-study | direct-fanti | Subtype structure depends on measures/sample |
| E003 | CONSTRUCT-HETEROGENEITY | motivates | STUDY-2016-FEAR | high | moderate | A | exact | mechanistic | n/a | single-study | direct-fanti | Historical continuation stronger than causal inference |
| E004 | STUDY-2016-FEAR | supports | CONSTRUCT-FEARLESS | high | moderate | A | exact | intermediate | n/a | single-study | direct-fanti | Subgroup association supports candidate pathway, not intervention target validity |
| E005 | STUDY-2016-FEAR | supports | CONSTRUCT-HETEROGENEITY | high | high | A | exact | theoretical | n/a | single-study | direct-fanti | Opposite fear profiles among similar CP phenotypes |
| E006 | STUDY-2016-NEUROCOG | constrains | CONSTRUCT-HETEROGENEITY | medium | moderate | B | exact | mechanistic | n/a | single-study | direct-fanti | Some neurocognitive deficits cut across CU subtypes; heterogeneity is not universal across every mechanism |
| E007 | STUDY-2017-MULTIPSY | supports | MECH-AUTONOMIC | high | moderate | B | exact | proximal | acute task | single-study | direct-fanti | Physiological correlates differ by psychopathy dimension |
| E008 | STUDY-2017-STARTLE | supports | MECH-FEARREACT | high | moderate | B | exact | proximal | acute task | single-study | direct-fanti | Forensic adolescent sample; subtype-specific threat physiology |
| E009 | STUDY-2018-NEUROHET | supports | CONSTRUCT-HETEROGENEITY | high | moderate | B | adjacent | mechanistic | acute task | single-study | direct-fanti | Cross-age comparative evidence; not one-to-one across age groups |
| E010 | STUDY-2019-META | supports | CONSTRAINT-BIOMARKER | high | high | B | broad | theoretical | meta-analysis | meta-analysis-66-studies | direct-fanti | Pooled evidence varies by system/task/design |
| E011 | CONSTRAINT-BIOMARKER | constrains | MECH-AUTONOMIC | high | high | B | broad | mechanistic | n/a | meta-analytic | direct-fanti | Autonomic measures may be informative but are not a universal signature |
| E012 | STUDY-2019-VRFEAR | operationalizes | INT-VR-MEASURE | high | high | A | exact | methodological | acute | single-study | direct-fanti | VR is an elicitation environment here, not therapy |
| E013 | STUDY-2019-VRFEAR | supports | MECH-FEARREACT | high | moderate | A | exact | proximal | acute | single-study | direct-fanti | Trait associations in nonclinical young adults |
| E014 | STUDY-2020-EYEGAZE | supports | MECH-ATTENTION | high | moderate | B | exact | proximal | acute | single-study | direct-fanti | Overall gaze/recognition differences present |
| E015 | STUDY-2020-EYEGAZE | supports | CONSTRAINT-EYENEGLECT | high | moderate | B | exact | theoretical | acute | single-study | direct-fanti | Expected eye-region-specific deficit not cleanly supported |
| E016 | STUDY-2024-ATTN | supports | CONSTRAINT-EYENEGLECT | high | moderate | B | exact | theoretical | acute | single-study | direct-fanti | Emotion recognition null; gaze depends on CU operationalization |
| E017 | STUDY-2024-ATTN | constrains | MECH-EMOREC | medium | moderate | B | exact | proximal | acute | single-study | direct-fanti | High CU does not necessarily imply poorer recognition in this sample |
| E018 | STUDY-2022-CHILDPSY | supports | MECH-AUTONOMIC | medium | moderate | B | exact | proximal | acute | single-study | direct-fanti | Extends physiological correlates into childhood |
| E019 | STUDY-2023-FACIAL | constrains | CONSTRUCT-CU | medium | moderate | B | exact | mechanistic | acute | single-study | direct-fanti | Facial-reactivity atypicality was not clearly CU-specific |
| E020 | STUDY-2014-PARENTCU | supports | CONSTRUCT-PARENTING | high | moderate | B | exact | intermediate | longitudinal | single-study | direct-fanti | CU moderates parenting-distress/conduct associations |
| E021 | STUDY-2023-PARENTPHYS | supports | CONSTRUCT-PARENTING | high | moderate | B | exact | intermediate | 1-year | single-study | direct-fanti | Physiology conditions person-context associations |
| E022 | STUDY-2023-PARENTPHYS | supports | MECH-AUTONOMIC | high | moderate | B | exact | intermediate | 1-year | single-study | direct-fanti | Moderation evidence, not mediation/causal manipulation |
| E023 | STUDY-2023-FEARLESS | supports | CONSTRUCT-FEARLESS | high | moderate | B | exact | intermediate | 8 years | single-cohort | direct-fanti | Longitudinal pathway supports temporal ordering |
| E024 | STUDY-2023-FEARLESS | supports | CONSTRUCT-PARENTING | high | moderate | B | exact | intermediate | 8 years | single-cohort | direct-fanti | Parenting participates in indirect pathways |
| E025 | STUDY-2024-INTERFEAR | formalizes | THEORY-INTERFEAR | high | high | A | exact | theoretical | 5 years | single-cohort replication/test | direct-fanti | Longitudinal model; still observational |
| E026 | CONSTRUCT-FEARLESS | integrates-with | CONSTRUCT-PARENTING | high | moderate | A/B | exact | theoretical | longitudinal | multiple-studies | direct-fanti | Transactional, not deterministic |
| E027 | CONSTRUCT-CU | integrates-with | THEORY-INTERFEAR | high | moderate | A | exact | theoretical | 5 years | single-cohort | direct-fanti | CU appears as mediator in model, not sole cause |
| E028 | THEORY-INTERFEAR | predicts | OUT-CD | high | moderate | A | exact | distal | 5 years | single-cohort | direct-fanti | Longitudinal prediction/mediation is not experimental treatment proof |
| E029 | STUDY-2018-SCHOOL | operationalizes | INT-SCHOOL | high | high | A* | exact | intervention | 3/9 months | single-pilot | direct-fanti | Only three clusters; one treated school |
| E030 | INT-SCHOOL | changes | OUT-CU | high | moderate | A* | exact | distal | 3/9 months | single-pilot | direct-fanti | Association with treatment condition; cluster confounding limits causal strength |
| E031 | INT-SCHOOL | changes | OUT-CD | high | moderate | A* | exact | distal | 9 months | single-pilot | direct-fanti | One intervention cluster; no independent replication located |
| E032 | STUDY-2024-PARENTCHILD | operationalizes | INT-PARENTCHILD | high | high | B | exact | intervention | post-intervention | single-study | direct-fanti | Program-specific comparative details not hardened |
| E033 | INT-PARENTCHILD | changes | OUT-EMOREC | high | moderate | B | exact | proximal | post-intervention | single-study | direct-fanti | Primary abstract supports pooled improvement, not specific-program superiority |
| E034 | INT-PARENTCHILD | changes | OUT-PHYSREG | high | moderate | B | exact | proximal | post-intervention | single-study | direct-fanti | Skin-conductance reactivity changed; distal behavior not established |
| E035 | STUDY-2020-CTBS | operationalizes | INT-CTBS | high | high | A | exact | intervention | acute | single-study | direct-fanti | Single-session cTBS |
| E036 | INT-CTBS | changes | OUT-EMOREC | high | high | A | exact | proximal | acute | single-study | direct-fanti | Selected emotion-recognition effects; APD group is moderator only |
| E037 | STUDY-2020-CTBS | supports | MECH-DLPFC | high | high | A | exact | proximal | acute | single-study | direct-fanti | Causal contribution to selected emotion-recognition performance |
| E038 | STUDY-2020-CTBS | motivates | STUDY-2025-CTBSAMT | high | high | A | adjacent | historical | 5 years later | direct continuation | direct-fanti | 2020 paper proposes combination with attention modification |
| E039 | STUDY-2025-CTBSAMT | operationalizes | INT-AMT | high | high | A | exact | intervention | 2 weeks | single-feasibility-trial | direct-fanti | AMT combined with active/sham cTBS |
| E040 | STUDY-2025-CTBSAMT | supports | OUT-ATTENTION | high | high | A | exact | proximal | post-intervention | single-feasibility-trial | direct-fanti | Positive attention/gaze effects |
| E041 | STUDY-2025-CTBSAMT | supports | CONSTRAINT-CTBS-ANX | high | high | A | exact | distal | post-intervention | single-feasibility-trial | direct-fanti | No superiority of active cTBS+AMT over sham cTBS+AMT for anxiety |
| E042 | CONSTRAINT-CTBS-ANX | constrains | OUT-ANXIETY | high | high | A | exact | distal | post-intervention | single-feasibility-trial | direct-fanti | AMT symptom change cannot be attributed to added active cTBS |
| E043 | STUDY-2025-CTBSATTN | supports | MECH-DLPFC | high | high | A | exact | proximal | acute | single-study | direct-fanti | Additional DLPFC manipulation evidence for emotional attention |
| E044 | INT-CTBS | changes | OUT-ATTENTION | high | high | A | exact | proximal | acute | single-study | direct-fanti | Acute emotional-attention effect in healthy adults |
| E045 | STUDY-2020-CTBS | does-not-establish | OUT-ASPD | high | high | A | mismatch | distal | none | single-study | direct-fanti | APD symptoms not remeasured; no clinical ASPD sample |
| E046 | STUDY-2026-KEYNOTE | claims | OUT-ASPD | high | low | D | unspecified | distal | unspecified | conference-synthesis | direct-fanti | Keynote wording extends beyond located direct stimulation outcome evidence |
| E047 | STUDY-2026-KEYNOTE | creates-open-gate | GAP-ASPD | high | high | D | unspecified | distal | unspecified | conference-synthesis | direct-fanti | Direct symptom-reduction evidence not located |
| E048 | STUDY-2021-HRV | operationalizes | INT-HRV | high | high | C | exact | intervention | post-intervention | single-dissertation | fanti-lab | Wait-list control; no follow-up |
| E049 | INT-HRV | changes | OUT-PHYSREG | high | moderate | C | exact | proximal | post-intervention | single-dissertation | fanti-lab | Subgroup/task-specific SC and LF/HF changes |
| E050 | STUDY-2021-HRV | supports | MECH-PHYSREG | high | moderate | C | exact | proximal | post-intervention | single-dissertation | fanti-lab | Interpretation as emotional regulation remains qualified |
| E051 | STUDY-2026-KEYNOTE | claims | OUT-CU | high | low | D | unspecified | distal | unspecified | conference-synthesis | direct-fanti | HRV-related CU reduction claim not matched to direct result in audited dissertation |
| E052 | STUDY-2026-KEYNOTE | creates-open-gate | GAP-HRV-CU | high | high | D/C | mismatch | distal | none | unresolved | mixed | Dissertation uses CU primarily as grouping/moderator variable |
| E053 | STUDY-2026-HAB | operationalizes | INT-COGMOD-UMBRELLA | high | moderate | D | adjacent | intervention | conference-stage | unpublished/conference | direct-fanti/fanti-lab | Multiple distinct paradigms; results not fully recoverable |
| E054 | STUDY-2026-KEYNOTE | claims | OUT-AGGR | high | low | D | unspecified | distal | unspecified | conference-synthesis | direct-fanti | Specific results-bearing direct source not located |
| E055 | STUDY-2026-KEYNOTE | claims | INT-VR-UMBRELLA | high | low | D | unspecified | intervention | unspecified | conference-synthesis | direct-fanti | Direct Fanti intervention provenance unresolved |
| E056 | STUDY-2019-VRFEAR | does-not-establish | INT-VR-UMBRELLA | high | high | A | mismatch | methodological | n/a | single-study | direct-fanti | Measurement/elicitation study cannot support treatment efficacy |
| E057 | STUDY-2026-KEYNOTE | creates-open-gate | GAP-VR | high | high | D | unspecified | distal | unspecified | conference-synthesis | direct-fanti | Adjacent Impact VR evidence cannot be directly attributed to Fanti |
| E058 | MECH-EMOREC | hypothesizes | OUT-AGGR | medium | low | B/D | transfer | distal | unknown | unresolved | mixed | Mechanism-to-behavior mediation not directly established in tech intervention branch |
| E059 | MECH-ATTENTION | hypothesizes | OUT-ANXIETY | high | moderate | A | adjacent | distal | post-intervention | single-feasibility-trial | direct-fanti | AMT-related symptom improvement plausible; added cTBS not supported |
| E060 | MECH-PHYSREG | hypothesizes | OUT-CU | medium | low | C/D | mismatch | distal | none | unresolved | mixed | Physiological change does not establish CU-trait reduction |
| E061 | CONSTRUCT-HETEROGENEITY | motivates | GAP-PRECISION | medium | low | transfer | translation | none | unresolved | Heterogeneity motivates personalization conceptually; prospective treatment matching not established | ||
| E062 | STUDY-2024-PARENTCHILD | supports | MECH-EMOREC | high | moderate | B | exact | proximal | post-intervention | single-study | direct-fanti | Emotion-recognition process appears modifiable |
| E063 | STUDY-2024-PARENTCHILD | supports | MECH-AUTONOMIC | high | moderate | B | exact | proximal | post-intervention | single-study | direct-fanti | Autonomic response to sadness appears modifiable |
| E064 | STUDY-2018-SCHOOL | does-not-establish | GAP-PRECISION | high | high | A* | mismatch | translation | 9 months | single-pilot | direct-fanti | Broad prevention efficacy does not establish biomarker-guided matching |
