Evidence-Gated Genealogy v1 — Structured Substrate

Purpose

This is the first integrated genealogy in which every explanatory transition is represented by typed nodes and typed edges rather than prose chronology alone. It is the substrate for the later temporal/fork-and-cascade visual atlas.

Major supported pathways

1. Developmental heterogeneity → differentiated mechanisms

developmental trajectories / CU variants → heterogeneity / equifinality → fear/fearlessness, threat reactivity, autonomic response, neurocognition, attention

The strongest conclusion is not that one biological mechanism explains antisocial behavior, but that similar outward phenotypes can arise through distinguishable developmental and psychophysiological configurations.

2. Transactional development remains parallel to neuroscience

fearlessness ↔ parenting / parental distress → CU development → conduct problems

The 2023–2024 longitudinal work integrates temperament and environment rather than replacing one with the other.

3. Psychophysiology → constraint, not a universal biomarker

multi-system physiological studies → 2019 meta-analysis → constraint: no single low-arousal/autonomic signature adequately characterizes all conduct-problem/CU presentations.

4. Emotion-processing branch → increasingly specific mechanism tests

emotion recognition / gaze / facial response → theory refinement → DLPFC manipulation → acute emotion-recognition and attention effects

This is a genuine causal-method transition, but the supported endpoint remains principally proximal cognitive processing.

5. Intervention history bifurcates by endpoint distance

Broad prevention: school skill-building → distal CU/CD outcomes with follow-up, but severe cluster-design limitations.

Mechanism-targeted relational intervention: parent-child emotion programs → sadness-recognition and physiological-response change, with distal behavior/trait outcomes not established in the primary source hardened for v1.

Technology-enhanced interventions:

cTBS / AMT → attention and emotion-processing changes; additive symptom efficacy is uneven.
HRV biofeedback → physiological regulation changes; CU-trait reduction remains open.
cognitive-modification conference programs → intervention identity established more securely than outcome efficacy.
VR → direct Fanti measurement lineage is established; direct Fanti efficacy attribution for the 2026 composite claim remains open.

Four classes of edges

Supported cascade: historical and evidentiary confidence both moderate/high.
Historical cascade / weak inference: later work clearly follows the earlier problem, but the stronger scientific proposition remains unproven.
Constraint branch: later evidence narrows or contradicts a simpler earlier account.
Open cascade: the research program points toward a clinical/translation claim but the next evidence gate is empty.

Non-negotiable open gates before rendering

Emotion-recognition/attention change does not equal reduction in antisocial behavior or ASPD symptoms.
Physiological regulation change does not equal CU-trait reduction.
Adjacent VR-company RCT evidence does not equal direct Fanti efficacy evidence.
Developmental heterogeneity does not yet equal prospective precision-treatment matching.
School-based distal outcomes and neurotechnology proximal outcomes must remain visually distinguishable rather than ranked by technological sophistication.

Rendering directive

The visual genealogy should use chronology as the horizontal spine, research streams as vertical lanes, and edge style as epistemic status:

solid = documented and evidentially supported;
dashed = historically strong but scientifically incomplete;
dotted = tentative/open translation;
barred/constraint marker = later evidence limits the proposed chain.

See Canonical-Node-Registry-v1, Evidence-Gated-Edge-Register-v1, and Consistency-Check-Report-v1.