1 · Developmental foundations

Heterogeneity / equifinality

Construct · B · cross-pop

2016 Fear / fearlessness

Study · A · child

Fearlessness

Construct · A/B · developmental

Parenting / distress

Construct · A/B · developmental

2 · Mechanisms become measurable

2019 Psychophysiology meta-analysis

Study · B · child/adolescent

Constraint: no universal biomarker

Constraint · B · cross-pop

Autonomic regulation

Mechanism · B/C · cross-pop

Emotion recognition

Mechanism · A/B · cross-pop

Attention / gaze

Mechanism · A/B · cross-pop

2020 cTBS / emotion recognition

Study · A · healthy young adults

DLPFC emotional processing

Mechanism · A · young adult

2019 VR fear elicitation

Study · A · young adult

3 · Intervention and integration

2018 School prevention

Study · A* · child

School intervention

Intervention · A* · child

2021 HRV biofeedback

Study · C · young adult

HRV + Zukor Drive

Intervention · C · young adult

2024 Parent-child intervention

Study · B · high-CU child

Parent-child emotion training

Intervention · B · high-CU child

INTERFEAR model

Theory · A · child development

4 · Neurotechnology translation and open gates

2025 cTBS + AMT

Study · A · community young adults

Constraint: no added cTBS anxiety efficacy

Constraint · A · young adult

2026 VR intervention umbrella

Intervention family · D · mixed

2026 intervention synthesis

Theory · D · mixed

OPEN: ASPD symptom reduction

Evidence gap · D · adulthood

OPEN: HRV → CU reduction

Evidence gap · D/C · young adult

OPEN: Fanti VR composite efficacy

Evidence gap · D · mixed

OPEN: precision treatment matching

Evidence gap · clinical/forensic

supportsmotivatessupportssupportssupportsconstrainsintegrates-withoperationalizesoperationalizessupportsmotivatessupportsOPEN · creates-open-gateoperationalizesOPEN · creates-open-gateOPEN · claimsdoes-not-establishOPEN · creates-open-gateOPEN · motivatessupportssupportsdoes-not-establish
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